I updated game about an hour ago. I just tried to play my hard difficulty saved game. I began a new character (last one died recently). About 20 moves into the game I was fighting a blue crystal creature with the help of a pair of skeletons. I threw a random potion to ID it and it spawned armor. Picked up armor and tried to equip it.

Then, either during the equipment change or during the monster's move just after, a teleport sound was made and then my game was mangled. See screen shot.

I can still use the UI, but can't move or use anything that requires selecting a location. I can't kill myself...game file is effectively lost.